The requirement of BDNF for hippocampal synaptic plasticity is experience‐dependent
نویسندگان
چکیده
منابع مشابه
The requirement of BDNF for hippocampal synaptic plasticity is experience‐dependent
Brain-derived neurotrophic factor (BDNF) supports neuronal survival, growth, and differentiation and has been implicated in forms of hippocampus-dependent learning. In vitro, a specific role in hippocampal synaptic plasticity has been described, although not all experience-dependent forms of synaptic plasticity critically depend on BDNF. Synaptic plasticity is likely to enable long-term synapti...
متن کاملIntegrin requirement for hippocampal synaptic plasticity and spatial memory.
The establishment of memory requires coordinated signaling between presynaptic and postsynaptic terminals in the CNS. The integrins make up a large family of cell adhesion receptors that are known to mediate bidirectional signaling between cells or between cells and their external environment. We show here that many different integrins, including alpha3 and alpha5, are expressed broadly in the ...
متن کاملKinase-Independent Requirement of EphB2 Receptors in Hippocampal Synaptic Plasticity
During development, Eph receptors mediate the repulsive axon guidance function of ephrins, a family of membrane attached ligands with their own receptor-like signaling potential. In cultured glutamatergic neurons, EphB2 receptors were recently shown to associate with NMDA receptors at synaptic sites and were suggested to play a role in synaptogenesis. Here we show that Eph receptor stimulation ...
متن کاملThe effect of ketamine on synaptic transmission and synaptic plasticity in CA1 area of rat hippocampal slices
The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was ...
متن کاملSynaptic plasticity: hippocampal LTP.
One of the most intensively studied forms of synaptic plasticity is long-term potentiation (LTP). The past year has seen further evidence advanced on both sides of the presynaptic/postsynaptic locus of expression debate, without an obvious path to reconcile the two views. Real progress has been made, however, in clarifying the possible role of nitric oxide as a retrograde messenger and the cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Hippocampus
سال: 2016
ISSN: 1050-9631,1098-1063
DOI: 10.1002/hipo.22555